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KMID : 0861020060210020159
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Korea Journal of Herbology
2006 Volume.21 No. 2 p.159 ~ p.163
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A 4-weeks Oral Toxicity of Dangguibohyel-tang in Sprague-Dawley Rats
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Kang Soon-Ah
Chang Mun-Seog
Oh Myung-Sook
Park Wan-Su
Kim Won-Nam
Yang Woong-Mo
Lee Byoung-Hee
Park Seong-Kyu
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Abstract
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Objectives: The subacute toxicity was investigated in Sprague-Dawley rats orally treated with Dangguibohyel-tang (DBT). DBT has been used for anemia, in Korean medicine.
Methods: Sprague-Dawley rats were administered orally with DBT at the dosages of 1,000 mg/kg for 14 days. We daily examined number of deaths, clinical signs, body weights and gross findings during the 14 days.
Results: There were no clinical signs and pathological changes compared with control group. Body weights were not significantly changed between control and treatment groups. In hematological and biochemical serum parameters, all mean values appear to be within the normal range.
Conclusions: These results suggest that DBT dose not induce any significant subacute oral toxicities in Sprague-Dawley rats.
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KEYWORD
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Dangguibohyel-tang (DBT), subacute toxicity, body weights, clinical signs
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